I love this so much! There are so many things screaming awesome with this piece. The plan to off the ol' lady, the trail of mousetraps showing that this is a continuous problem, the 'perspective' choice and how the top/bottom warp through the ceiling, down to the colors and color scheme. This is a great start and I cannot wait to see where this goes.
Feedback is minimal really:
I love the heavy lines and jowls that emphasizes how old the lady is. Someone mentioned they didn't notice she was a 'she' at first. I think the lips could use a little more punch but I feel like you have the right plan with the curlers. They are a great way to show that its a woman and will show after cleanup.
The light-bulb is vital to showing that the warped part is a ceiling and meshing the two areas, however I don't like the center placement. My eye wants to go to the mice but I keep getting drawn to the strong silhouette of the light socket.
I think that the warping of the ceiling is a little too wide on both ends. I want to see those mice feet.